Author: Tahira S. Khokhar, Shahabuddin Memon, Qadeer K. Panhwar, Fakhar N Memon, Ayaz A. Memon, Muhammad Qasim Samejo, Saba Muneer and Metin Tulu
Publishing Date: 2017
E-ISSN: 1011-601X
Volume 30 Issue 3
ABSTRACT:
Complexation of ibuprofen with water soluble p-sulfonatocalix[4]arene (3) was evaluated. Both molecules exhibit a host and guest type complexation. pH, complex stoichiometry and binding constant were determined by UV-Vis and FT-IR spectroscopy. The maximum complexation of 3 with ibuprofen occurs at pH 2. Stability constant values (9.897) show that there is favorable complex formed due to vital role of p-sulfonatocalix[4]arene, while the thermodynamic parameters, i.e. ΔG, ΔH and ΔS have been found as -24.09 KJ/mol, 0.012 KJ/mol and 0.12 KJ/mol. K, respectively. The results show that 3 has efficiency to carry the drug at particular conditions and can be used for drug delivery as a carrier.
KEYWORDS: Synthesis, inclusion complex, p-sulfonatocalix[4]arene, thermodynamic, drug delivery.