Author: Mohammad Reza Mohammadi, Amir Hossein Omidi2, Hoda Sabati
Publishing Date: 2022
E-ISSN: 2823-2550
Volume: 2
Issue: 3
DOI: https://doi.org/10.55705/cmbr.2022.338888.1039
ABSTRACT:
SARS-CoV-2 is the causative agent of the global pandemic, also
known as Covid-19. This virus belongs to a group of coronaviruses
and has affected more than ten million people across the globe,
causing nearly half a million deaths worldwide. The pandemic has
spread worldwide, originating in the Wuhan Hubei province of
China in 2019. The disease is a significant challenge as there is no
antiviral treatment. This review will address current trends and
emerging new methods for detecting SARS-CoV-2 in the
laboratoryat present. Reverse transcriptase PCR or RT-PCR is the
gold standard for detecting SARS-CoV-2 disease. The seroprevalence
of Covid-19 is performed using antibody detection tests using ELISA
and antigen detection as rapid tests. In clinical practice, preliminary
disease identification is made based on Chest radiographs,
computed tomography, and positron emission tomography (PET)
scans. As the pandemic has progressed, newer methods of detection
like CRISPR, nanotechnology-enabled solutions, and biosensors have
emerged as new methods of detecting SARS-CoV-2.
Key Words: Reverse transcriptase PCR, Nanotechnology, CRISPR, Biosensors, Artificial intelligence, Positron emission tomography