Author: Darakhshan Masroor, Sadia Ghousia Baig , Salman Ahmed , Syed Muzzammil Ahmad and Muhammad Mohtasheem ul Hasan
Publishing Date: 2018
E-ISSN: 1011-601X
Volume 31 Issue 2
ABSTRACT:
Analgesic, anti-inflammatory and diuretic activities of the methanol extract of two varieties of Cicer arietinum viz black or Desi and white or Kabuli were tested in the doses of 200 and 400 mg/kg. For analgesic effect of the extracts, acetic acid induced writhing, tail immersion and hot plate tests were employed in mice. The anti-inflammatory activity was carried out by carrageenan induced inflammation in rats, whereas the diuretic action was determined using metabolic cages for rats. Animals were divided into six groups (n=7): (1) Control (2) Standard (3) MECAB 200 (4) MECAB 400 (5) MECAW 200 (6) MECAW 400. All extracts and standard drugs were administered orally. Acute oral toxicity of the extracts was also checked in mice up to 2000mg/kg dose, which showed a favorable safety. Significant analgesic and anti-inflammatory effects were observed. The results of diuretic activity were significant at 12th and 24th hrs. Therefore, it is concluded that the methanol extracts of the seeds of Cicer arietinum have analgesic, antiinflammatory and diuretic potential.
Keywords: Cicer arietinum, analgesic, anti-inflammatory, diuretic, methanol extract.