Author: Matthias Onyebuchi Agbo, Damian Chukwu Odimegwu, Festus Basden Chiedu Okoye, Patience Ogoamaka Osadebe
Publishing Date: 2017
E-ISSN: 1011-601X
Volume 30 Issue 4
ABSTRACT:
Isolated Salidroside from the leaves of Nigerian mistletoe (Loranthus micranthus Linn) parasitic on Hevea brasiliensis was evaluated for its antiviral activity against respiratory syncytial virus. Semi- preparative HPLC separation of the ethyl acetate fraction of the leave extract of Loranthus micranthus Linn parasitic on Hevea brasiliensis led to the isolation of a polyphenol. Using spectroscopic methods (1D and 2D NMR and mass spectroscopic data) as well as by comparison with literature data the structure of the compound was determined as 6-O-galloyl salidroside. The antiviral activity of the isolated compound was evaluated against the respiratory syncytial virus. The isolated Salidroside showed potent inhibition towards a recombinant straining respiratory syncytial virus with Inhibitory Concentration (IC50) value of 10.3±1.50 µg/mL. The result indicates that Salidroside is an efficient antiviral agent against RSV infection and might be useful for the management of RSV pathogenesis.
Keywords: hRSV, Loranthus micranthus Linn, Salidroside, structure elucidation, anti-hRSV activity